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. 2016 Dec 8;9(2):213–230. doi: 10.1080/19420862.2016.1267089

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© 2017 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 6. — Efficient production of anti-HER2/CD3 BsIgG₁ v10 in stable CHO cell lines. (A) Waterfall plot of individual CHO clones showing the percentage of BsIgG present in the protein A-purified IgG pool as estimated by high-resolution liquid chromatography-MS.¹⁹ (B) Shake flask production of BsIgG anti-HER2/CD3 BsIgG₁ v10 clones 3, 5 and 7 is stable over time. (C) Similar percentage of BsIgG₁ for clone 7 cultured in either a shake flask or bioreactor.