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Equilibrium binding to human FcRn and FcγRs, KD (nM), determined by ProteOn for Fc mutants for Bs4Ab-VA and the anti-VEGF parental antibody.
| YTE |
|
|
| Fc receptor | anti-VEGF | Bs4Ab-VA |
| FcRn |
118 |
123 |
| 3M |
|
|
| Fc receptors | anti-VEGF | Bs4Ab-VA |
| FcγRIIIA-158F |
227 |
188 |
| TM |
|
|
| Fc receptors | anti-VEGF | Bs4Ab-VA |
| FcγRI | 259 | 273 |
| FcγRIIIA-158V | 2600 | 2900 |
| FcγRIIIA-158F | 10100 | 13100 |
