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CD8 KO reduces cytotoxicity and cell apoptosis in obstructed kidney. (A–D) mRNA expression levels of PRF-1, GZMA, GZMB, and FASL in whole kidney tissues were analyzed by quantitative RT-PCR (* p < 0.05, CD8 KO vs. WT; n = 5); (E) TUNEL staining is performed in kidney; TUNEL (green), nucleus (blue). The percentage of TUNEL-positive cells in total cells is calculated (n = 5, * p < 0.05).
