Figure 4.

The effects of HIF-1α knockdown on CCH-induced angiogenesis. (A) Representative images of FITC-dextran-perfused vessels in the hippocampus, cortex, and corpus callosum four weeks after 2VO or sham surgery with or without HIF-1α-knockdown treatment. Bar = 300 µm (the magnification of all images is consistent); (B) the quantitative capillary density. Capillary density was expressed as the number of capillaries (diameter <12 µm) per square millimeter. Values are expressed as mean ± SEM (n = 4). * p < 0.05 (One-way ANOVA followed by Bonferroni post hoc tests).