Table 5.
Effects of dietary supplementation of elderberry polar and lipophilic extracts on the rats’ blood morphology and hematology indices. Diabetic rats without dietary supplementation and non-diabetic rats were also followed-up.
| Index | Non-Diabetic Rats (n = 5) | Diabetic Rats with High-Fat Diets | ||
|---|---|---|---|---|
| Not Supplemented (n = 8) | Polar Extract (n = 7) | Lipophilic Extract (n = 6) | ||
| RBC (1012/L) | 9.42 ± 0.17 a | 9.77 ± 0.46 a | 9.88 ± 0.54 a | 9.50 ± 0.37 a |
| HGB (mmol/L) | 15.24 ± 0.38 a | 15.95 ± 0.56 a | 16.13 ± 0.82 a | 15.53 ± 0.39 a |
| Hematocrit (%) | 44.64 ± 1.58 a | 46.14 ± 2.28 a | 44.57 ± 3.01 a | 43.28 ± 1.70 a |
| MCV (10−15 L) | 47.39 ± 1.32 a | 47.30 ± 2.77 a | 45.17 ± 2.78 a | 45.63 ± 2.82 a |
| MCH (10−15 kg) | 16.18 ± 0.23 a | 16.40 ± 0.87 a | 16.34 ± 0.62 a | 16.37 ± 0.42 a |
| MCHC (10−2 kg/L) | 34.14 ± 0.55 a | 34.71 ± 1.04 a,b | 36.23 ± 1.01 b | 35.92 ± 1.33 a,b |
| WBC (109/L) | 4.51 ± 1.04 a | 2.80 ± 0.98 b | 3.03 ± 0.49 b | 2.97 ± 0.68 b |
| MONO (103/μL) | 0.44 ± 0.15 a | 0.17 ± 0.08 b | 0.24 ± 0.06 b | 0.21 ± 0.09 b |
| LYMPH (103/μL) | 3.72 ± 1.01 a | 1.92 ± 0.53 b | 2.35 ± 0.51 a,b | 2.38 ± 0.63 a,b |
| PLT (1012/L) | 1129 ± 99 a | 866 ± 129 b,c | 960 ± 114 a,c | 855 ± 144 b,c |
| PDW (10−15/L) | 9.10 ± 0.44 a | 9.54 ± 0.24 a | 9.73 ± 0.56 a | 10.22 ± 1.52 a |
| MPV (10−15/L) | 7.92 ± 0.20 a | 8.11 ± 0.29 a | 8.04 ± 0.51 a | 8.25 ± 0.41 a |
| p-LCR (%) | 10.70 ± 1.60 a | 12.13 ± 1.91 a | 11.86 ± 3.71 a | 13.20 ± 3.25 a |
| RDW-SD (10−15 L) | 30.68 ± 1.72 a | 35.45 ± 1.96 b | 33.01 ± 2.01 a,b | 33.58 ± 2.07 a,b |
Values expressed as mean ± SD; Mean values with unlike letters in rows show statistically significant differences (p < 0.05, LSD’s Fisher test); RBC—red blood cell count; HGB—blood hemoglobin concentration; MCV—mean corpuscular volume; MCH—mean corpuscular hemoglobin; MCHC—mean corpuscular hemoglobin concentration; WBC—white blood cell count; MONO—monocyte count; LYMPH—lymphocyte count; PLT—platelet count; PDW—platelet distribution width; MPV—mean platelet volume; p-LCR—platelet large-cell ratio; RDW-SD—red cell distribution width based on standard deviation.