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. 2016 Dec 27;18(1):38. doi: 10.3390/ijms18010038

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of vitamin C on articular cartilage of rat with MIA-induced OA. The details of MIA-induced OA in rats and subsequent vitamin C treatment are described in the Materials and Methods. After vitamin C treatment for two weeks, the articular cartilage of rats was removed and (A) macroscopic observation or (B) histologic evaluation or (C) Osteoarthritis Research Society International (OARSI) score of each joint occurred, n = 10. * p < 0.05 compared to the untreated control. # p < 0.05 compared to the MIA treated group.