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Effect of vitamin C on the serum levels of pro-inflammation cytokines and MMPs in rats with MIA-induced OA. The details of MIA-induced OA in rats and subsequent vitamin C treatment are described in the Materials and Methods. After vitamin C treatment for two weeks, serum levels of IL-6, TNF-α, and MMP-13 were analyzed by enzyme-linked immunoassay n = 10. * p < 0.05 compared to the untreated control. # p < 0.05 compared to the MIA treated group.
