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. 2016 Dec 29;18(1):65. doi: 10.3390/ijms18010065

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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FN + MP.BDNF and LM + MP.NGF/NT3 enhance motor and sensory functional recovery, respectively. (A,B) Mean amplitude of the CMAP in TA (A) and PL (B) muscles during follow-up. ** p < 0.01 and *** p < 0.001 FN + MP.BDNF vs. all other groups referenced by the color of the star. (C) Pinprick score in the different groups during follow-up; * p < 0.05. (D) Latency of withdrawal response to thermal stimuli in the lateral part of the paw during follow-up; ** p < 0.01 and *** p < 0.001 LM + MP.NGF/NT3 vs. all other groups referenced by the color of the star. (E–J) Representative images of plantar pads immunolabeled against PGP in: an intact rat (E); COL (F); LM (G); LM + MP.NGF/NT3 (H); FN (I); and FN + MP.BDNF (J) treated animals. Insets: Detail of axons stained with PGP innervating epidermis and SGs. (K,L) Percentage of reinnervated IENF (K) and reinnervated SGs (L) vs. intact values. * p < 0.05, ** p <0.01 and *** p < 0.001. Data is presented as mean ± SEM.

FN + MP.BDNF and LM + MP.NGF/NT3 enhance motor and sensory functional recovery, respectively. (A,B) Mean amplitude of the CMAP in TA (A) and PL (B) muscles during follow-up. ** p < 0.01 and *** p < 0.001 FN + MP.BDNF vs. all other groups referenced by the color of the star. (C) Pinprick score in the different groups during follow-up; * p < 0.05. (D) Latency of withdrawal response to thermal stimuli in the lateral part of the paw during follow-up; ** p < 0.01 and *** p < 0.001 LM + MP.NGF/NT3 vs. all other groups referenced by the color of the star. (E–J) Representative images of plantar pads immunolabeled against PGP in: an intact rat (E); COL (F); LM (G); LM + MP.NGF/NT3 (H); FN (I); and FN + MP.BDNF (J) treated animals. Insets: Detail of axons stained with PGP innervating epidermis and SGs. (K,L) Percentage of reinnervated IENF (K) and reinnervated SGs (L) vs. intact values. * p < 0.05, ** p <0.01 and *** p < 0.001. Data is presented as mean ± SEM.