Table 1.
Experimental conditions evaluated in the in vitro and in vivo studies.
| Group | Abbreviation | N | Description |
|---|---|---|---|
| In Vitro Condition | |||
| Collagen | COL | 8 | Collagen type I (3 mg/mL) gel |
| Collagen + NGF/NT3 | COL + NGF/NT3 | 7 | Collagen type I (3 mg/mL) gel supplemented with NGF and NT3 (25 + 25 ng/mL) |
| Collagen + BDNF | COL + BDNF | 6 | Collagen type I (3 mg/mL) gel supplemented with BDNF (50 ng/mL) |
| Laminin | LM | 8 | Collagen type I (3 mg/mL) gel containing 20% laminin type I |
| Laminin + NGF/NT3 | LM + NGF/NT3 | 7 | Collagen type I (3 mg/mL) gel containing 20% laminin type I and NGF + NT3 (25 + 25 ng/mL) |
| Laminin + BDNF | LM + BDNF | 7 | Collagen type I (3 mg/mL) gel containing 20% laminin type I and BDNF (50 ng/mL) |
| Fibronectin | FN | 6 | Collagen type I (3 mg/mL) gel containing 20% fibronectin |
| Fibronectin + NGF/NT-3 | FN + NGF/NT3 | 6 | Collagen type I (3 mg/mL) gel containing 20% fibronectin and NGF + NT3 (25 + 25 ng/mL) |
| Fibronectin + BDNF | FN + BDNF | 7 | Collagen type I (3 mg/mL) gel containing 20% fibronectin and BDNF (50 ng/mL) |
| In Vivo Condition | |||
| Collagen | COL | 6 | Collagen type I (3 mg/mL) gel |
| Laminin | LM | 6 | Collagen type I (3 mg/mL) gel containing 20% laminin type I |
| Collagen + NGF/NT3 * | MP.NGF/NT3 | 6 | Collagen type I (3 mg/mL) gel containing NGF + NT3 (1 + 1 µg/mL) encapsulated in PLGA microspheres |
| Laminin + NGF/NT3 | LM + MP.NGF/NT3 | 6 | Collagen type I (3 mg/mL) gel containing 20% laminin type I and NGF + NT3 (1 + 1 µg/mL) encapsulated in PLGA microspheres |
| Fibronectin | FN | 6 | Collagen type I (3 mg/mL) gel containing 20% fibronectin |
| Collagen + BDNF * | MP.BDNF | 6 | Collagen type I (3 mg/mL) gel containing 2 µg/mL of BDNF encapsulated in PLGA microspheres |
| Fibronectin + BDNF | FN + MP.BDNF | 6 | Collagen type I (3 mg/mL) gel containing 20% fibronectin and 2 µg/ml of BDNF encapsulated in PLGA microspheres |
* Only in the short term study.