Figure 13.
(a) Size exclusion radio-HPLC traces of [68Ga(THP-PhNCS-trastuzumab)] (red) and [68Ga(EDTA)]− (black); and (b) In vitro uptake of [68Ga(THP-PhNCS-trastuzumab)] and [68Ga(THP-PhNCS-trastuzumab)] in the presence of an inhibitory concentration of trastuzumab, and 68Ga3+ in HER2-positive HCC1954 cells, and [68Ga(THP-PhNCS-trastuzumab)] in HER2-negative A375 cells, after 30 min incubation. Uptake is expressed as a percentage of added radioactivity (AR)/1 × 106 cells (n = 3, error bars correspond to standard error of the mean).