Table 2.
Discriminatory value of serum angiogenesis markers expression showing significant p-values (p < 0.05) and area under the receiver operating characteristic (ROC) curve (AUC > 0.610) between studied groups.
| Angiogenesis Marker | OC vs. Control Group | Type I OC vs. Healthy Controls | Type II OC vs. Healthy Controls | OC vs. Benign Ovarian Tumours | ||||
|---|---|---|---|---|---|---|---|---|
| p-Value | AUC | p-Value | AUC | p-Value | AUC | p-Value | AUC | |
| FGF-basic | 0.0288 | 0.617 | - | - | 0.035 | 0.642 | 0.026 | 0.636 |
| Follistatin | 0.002 | 0.668 | - | - | 0.013 | 0.675 | <0.001 | 0.713 |
| G-CSF | - | - | - | - | 0.048 | 0.643 | - | - |
| sHER2/neu | - | - | 0.035 | 0.704 | - | - | - | - |
| HGF | 0.02 | 0.619 | - | - | 0.036 | 0.645 | 0.020 | 0.643 |
| Leptin | 0.001 | 0.669 | - | - | 0.005 | 0.696 | <0.001 | 0.715 |
| Osteopontin | <0.001 | 0.791 | - | - | <0.001 | 0.82 | <0.001 | 0.825 |
| PDGF-AB/BB | 0.008 | 0.636 | - | - | 0.019 | 0.645 | 0.001 | 0.652 |
| CA125 | - | - | - | - | - | - | <0.001 | 0.935 |
| HE4 | - | - | - | - | - | - | <0.001 | 0.946 |
The highest obtained AUC values are bolded; OC: ovarian cancer; AUC: area under the curve.