Table 2.
Group | Liver Function Tests | Lipid Profile | |||||||
---|---|---|---|---|---|---|---|---|---|
SGOT (U/mL) | SGPT (U/mL) | ALP (U/mL) | BIL (mg/dL) | TC (mg/dL) | HDL (mg/dL) | LDL (mg/dL) | VLDL (mg/dL) | TG (mg/dL) | |
Healthy Control | 38.43 ± 4.03 ** | 17.32 ± 1.16 ** | 23.39 ± 0.56 ** | 0.58 ± 0.05 ** | 62.24 ± 2.37 ** | 28.73 ± 3.25 ** | 27.4 ± 2.29 ** | 6.13 ± 0.46 ** | 30.62 ± 2.30 ** |
NIC-STZ Control | 346.94 ± 5.97 | 83.54 ± 2.20 | 134.91 ± 2.02 | 1.78 ± 0.05 | 213.69 ± 2.49 | 55.99 ± 6.33 | 138.65 ± 7.70 | 19.01 ± 0.34 | 95.12 ± 1.69 |
MET-treated Control | 261.48 ± 6.56 ** | 82.76 ± 2.82 ns | 127.8 ± 4.32 ns | 2.51 ± 0.11 ns | 174.58 ± 3.29 ** | 23.59 ± 3.91 ** | 137.82 ± 5.37 ns | 13.19 ± 0.54 ** | 65.96 ± 2.70 ** |
SWE | 104.54 ± 7.98 ** | 25.83 ± 1.38 ** | 119.66 ± 4.29 ** | 1.14 ± 0.08 ns | 125.17 ± 4.45 ** | 32.06 ± 3.02 ** | 81.77 ± 5.29 ** | 11.34 ± 1.72 ** | 56.71 ± 8.57 ** |
SHAE | 181.84 ± 4.39 ** | 53.7 ± 5.90 ** | 109.4 ± 2.23 ** | 2.44 ± 0.09 ns | 98.59 ± 2.93 ** | 41.5 ± 4.45 ns | 45.53 ± 5.57 ** | 11.56 ± 1.58 ** | 57.86 ± 7.88 ** |
SAE | 347.73 ± 0.97 ns | 49 ± 4.41 ** | 146.8 ± 0.03 * | 3.96 ± 0.50 ** | 127.13 ± 0.45 ** | 58.23 ± 1.76 ns | 51.57 ± 1.35 ** | 17.33 ± 0.08 ns | 86.6 ± 0.39 ns |
Results are a mean of three replicates and are represented as mean ± SE. * p ≤ 0.05; ** p ≤ 0.01 as compared to NIC-STZ control group (Dunnett Multiple Comparisons Test). SGOT: Serum glutamic oxaloacetic transaminase; SGPT: Serum glutamic pyruvic transaminase; ALP: Alkaline phosphatase; BIL: Total bilirubin; TC: Total Cholesterol; HDL: High-density lipoprotein; LDL: Low-density lipoprotein; VLDL: Very low-density lipoprotein; TG: Triglycerides. NIC-STZ: nicotinamide-streptozotocin, MET: Metformin, ns: Non-significant.