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. 2017 Jan 12;18(1):133. doi: 10.3390/ijms18010133

Figure 3.

Figure 3

Effect of hydrostatic pressure (HP) exposure immediately after pressurization (T0), and after 12 (T12), 24 (T24), and 48 (T48) h, on the expression levels of target genes MMP-13 (A), ADAMTS-5 (B), IGFBP-5 (C), and HDAC-4 (D) in normal (N) and osteoarthritic (OA) chondrocytes. N = normal cells with no HP exposure; N HP = normal cells subjected to HP; OA = OA cells with no HP exposure; OA HP = OA cells subjected to HP. Data are expressed as mean ± standard deviation of triplicate values. * p < 0.05; ** p < 0.01; *** p < 0.001 OA HP vs. OA T0; °° p < 0.01, °°° p < 0.001 OA HP vs. OA. MMP-13: matrix metalloproteinase 13; ADAMTS-5: disintegrin and metalloproteinase with thrombospondin motif 5; IGFBP-5: insulin-like growth factor binding protein 5; HDAC-4 histone deacetylase 4.