Table 1.

The pathogenic mechanism of acne and experimental design of our platform.

Pathogenesis of Acne Vulgaris	Epithelial Cell & Keratin Accumulation	Sebum Accumulation	Bacterial Growth	Skin Inflammation
In vitro experimental designs	Testosterone-induced HaCaT cell proliferation	Anti-lipase activity	Propionibacterium acnes Staphylococcus aureus	Heat-killed P. acnes-induced RAW 264.7 Heat-killed P. acnes-induced THP-1
Effective hydrolysable tannins	Punicalagin (1)	Punicalin (2)	Strictinin A (3)	Granatin B (4)

P. acnes: Propionibacterium acnes.