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. 2017 Jan 13;18(1):143. doi: 10.3390/ijms18010143

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© 2017 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Histopathological features of poorly differentiated small cell carcinoma and well-differentiated NET G3. (A) In small cell carcinoma, tumor cells with a high nuclear cytoplasmic ratio and small-sized ovoid nuclei grow in a solid pattern. Immunohistochemical analysis shows extremely high Ki-67 labeling index values (hematoxylin and eosin, and Ki-67 immunohistochemical staining, original magnifications ×400). Ki-67 immunohistochemical staining is shown in the upper right corner; (B) in NET G3, tumor cells with a moderate amount of cytoplasm and a low mitotic rate show a trabecular and glandular growth pattern. The Ki-67 labeling index is over 20%, but is not as high as that of small cell carcinoma (hematoxylin and eosin, and Ki-67 immunohistochemical staining, original magnifications ×200). Ki-67 immunohistochemical staining is shown in the upper right corner.