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. 2017 Jan 13;18(1):145. doi: 10.3390/ijms18010145

Figure 7.

Figure 7

Schematic illustration of the mechanism through which miR-34a-5p affects the hematopoietic progenitor cells proliferation and commitment. miR-34a-5p targets MYB, LEF1 and NR4A2 transcripts in HPCs, therefore leading to the downregulation of MYB, LEF1 and NR4A2 proteins (ellipses). By targeting MYB, miR-34a-5p impairs the hematopoietic progenitor cells proliferation and enhances the megakaryocyte and macrophage differentiation. In addition, miR-34a-5p targets LEF1 mRNA for degradation. LEF1 downregulation further enhances the hematopoietic progenitor cells commitment towards the megakaryocyte and macrophage lineages, while the miR-34a-5p-driven downregulation of NR4A2 negatively interferes with cell cycle progression. Therefore, miR-34a-5p restrains hematopoietic progenitor cells proliferation and favours their commitment toward the megakaryocyte and macrophage lineages by targeting LEF1 and NR4A2, together with MYB.