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. 2017 Jan 14;18(1):163. doi: 10.3390/ijms18010163

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© 2017 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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E2 reduces the cell death caused by MX in a dose-dependent manner in normal MCF-7 cell line. (A) E2 increased the cell viability in a dose-dependent manner which were co-treated with l μM MX in normal MCF7 cells.* p < 0.05, ** p < 0.01 indicate significant differences compared to the control group; (B) siERα inhibited the cell viability of normal MCF7 cells (l μM MX treatment) compared to the control group (E2 only) (+ represents the addition; - represents not addition); (C) E2 was treated with l μM MX in MCF7 cells and MDA-MB231 cells. The cell viability increased 25% in the E2 treatment group compared to the control group (MX only) in normal MCF7 cells while there was no significant difference in MDA-MB231 cells. &&& p < 0.001 indicates significant differences compared to the control group and *** p < 0.001 indicates significant differences compared to the MX treatment group.