Table 1.

The antifungal activity of the synthesized thiazolin-4-one derivatives (inhibition zone diameters (mm)).

2, 5, 8, 10, 11	Fluconazole	3a–h, 6a–e, 9a–e
Compound	R	Ar	C. albicans ATCC 10231
2	CH2=CH–CH2–NH–	-	20 ± 0.2
5	C6H5–NH–	-	22 ± 0.5
8	α-C10H7–NH–	-	24 ± 1
10	CH3–NH–	-	22 ± 1
11	C6H5–	-	18 ± 1
3a	CH2=CH–CH2–NH–		20 ± 0.5
6a	C6H5–NH–		20 ± 0.5
9a	α-C10H7–NH–		18 ± 1
3b	CH2=CH–CH2–NH–		20 ± 0.5
6b	C6H5–NH–		20 ± 1
9b	α-C10H7–NH–		18 ± 0.2
3c	CH2=CH–CH2–NH–		18 ± 1
6c	C6H5–NH–		20 ± 1
9c	α-C10H7–NH–		20 ± 0.5
3d	CH2=CH–CH2–NH–		20 ± 0.2
6d	C6H5–NH–		20 ± 1
9d	α-C10H7–NH–		20 ± 1
3e	CH2=CH–CH2–NH–		20 ± 0.5
6e	C6H5–NH–		16 ± 1
9e	α-C10H7–NH–		22 ± 0.5
3f	CH2=CH–CH2–NH–		22 ± 0.2
3g	CH2=CH–CH2–NH–		22 ± 0.2
3h	CH2=CH–CH2–NH–		20 ± 0.5
Fluconazole			22 ± 0.5

The value obtained for each compound represents the mean of three independent measurements ± SD. The values obtained for the most active compounds are marked in bold.