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. 2017 Jan 18;18(1):184. doi: 10.3390/ijms18010184

Figure 3.

Figure 3

Effect of CSP-1103 and ibuprofen on cytochrome c in cortical neurons exposed to OGD. (A) Representative images and (B) densitometry analysis of WB for Cyt C in cytosolic extracts after 2 h of recovery. CSP-1103, but not ibuprofen, reversed the OGD-induced cytochrome c release from mitochondria after 2 h of recovery. Bars (mean ± SEM) represent the percentage of the Cyt C/actin ratio relative to the OGD value. (C) Representative images and (D) densitometry analysis of WB for Cyt C in cytosolic extracts after 6 h of recovery. The pro-apoptotic release of cytochrome c was blocked by CSP-1103 treatment of neurons after 6 h of recovery. Bars (mean ± SEM) represent the percentage of the Cyt C/actin ratio, relative to the OGD value. *** p < 0.001 vs. OGD value. +, presence of OGD; −, absence of OGD or treatment.