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. 2017 Jan 18;18(1):184. doi: 10.3390/ijms18010184

Figure 5.

Figure 5

Effect of CSP-1103 and ibuprofen on nuclear levels of RelA in cortical neurons exposed to OGD. (A) Representative images and (B) densitometric analysis of WB for RelA in nuclear extracts after 2 h recovery. When added after the OGD, only CSP-1103 was able to revert the nuclear increase of RelA. Bars (mean ± SEM) represent the percentage of the RelA/actin ratio, relative to the OGD value; (C) ELISA analysis of the DNA binding activity of RelA in nuclear extracts prepared 2 h after the OGD. CSP-1103, but not ibuprofen, reduced the DNA binding activity of RelA. Bars (mean ± SEM) represent the percentage of the DNA binding activity over the basal value, relative to OGD. * p < 0.05, *** p < 0.001 vs. OGD value. +, presence of OGD; −, absence of OGD or treatment.