miR-34a |
SIRT1, FMNL2 and E2F5 |
Inhibition and induction of p53 acetylation |
[53,54] |
miR143 |
DNMT, KRAS |
Induction of cell proliferation |
[55] |
miR135 |
APC |
Suppression of WNT pathway |
[55] |
miR-29 |
DNMT 3A and 3B |
Reduction of methylation |
[56] |
miR-21 |
PDCD4 |
Invasion and metastasis promotion |
[57] |
miR-345 |
BAG |
Induction of cell proliferation and invasion |
[58] |
miR-148b |
CCK2R |
Induction of cell proliferation |
[59] |
Let-7c |
KRAS, MMP11 and PBX3 |
Metastasis induction |
[60] |
Let-7a |
Np95 ICBP90 RING finger |
Induction of cell proliferation |
[61] |
miR-499-5p |
FOXO4 and PDCD4 |
Induction of metastasis |
[62] |
miR-92 |
KLF4 |
Promotion of cell growth and migration |
[63] |
miR-126 |
SPRED1, PIK2R2/P85-β |
Inhibition of cell proliferation, migration and invasion |
[64] |
miR-320 |
FOXO4 and PDCD4 |
Inhibition of cell proliferation |
[65] |
miR-200 family |
JNK2 |
Inhibition of tumour growth and metastasis and induction of sensitivity to chemotherapeutic drugs |
[66] |
miR-9 |
TM4SF1 |
Suppression of cell migration and invasion |
[67] |
miR-503 |
calcium-sensing receptor |
Induction of proliferation migration and invasion |
[68] |
miR-222 |
MST3 |
Induction of invasion and migration |
[69] |
miR-181b |
RASSF1A |
Induce proliferation and enhance cell survival |
[70] |
miR-497 |
VEGFA |
Inhibition of invasion and metastasis |
[71] |
miR-152 |
PIK3R3 |
Tumour suppressor |
[72] |
miR-187 |
SOX4, NT5E and PTK6 |
Inactivation of TGF-β pathway and prevention of EMT (epithelial to mesenchymal transition) |
[73] |
miR-519 |
Orai1 |
Tumour suppression |
[74] |
miR-155 |
HMG-box transcription factor 1 |
Tumour suppressor by induction of WNT/β-catenin pathway |
[75] |
miR-497 |
KSR1 |
Tumour growth inhibition and enhancement of chemo sensitivity |
[76] |
miR-375 |
Bcl-2 |
Inhibition of tumour progression |
[77] |
miR-1246 |
CCNG2 |
Induction of cell growth and metastasis |
[78] |
miR-140-5p |
VEGFA |
Inhibition of tumour progression |
[78] |
miR-144 |
GSPT1 |
Inhibition of proliferation and migration |
[79] |
miR-638 |
Phospholipase D1 |
Inhibition of cell proliferation |
[80] |
miR-99b-5p |
mTOR |
Inhibition of metastasis formation |
[66] |
miR-101 |
SphK1 |
Inhibition of cell growth and increase of paclitaxel chemo-sensitivity |
[81] |
miR-20a |
TIMP-2 |
Induction of epithelial-to-mesenchymal transition (EMT) |
[82] |
miR-409-3p |
GAB1 |
Inhibition of tumour progression and metastasis |
[83] |