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Inhibition of the mTOR signal suppresses ER stress-induced cell death. Inhibition of mTOR maintains cellular proteostasis and attenuates ER stress by reducing misfolded protein synthesis. In addition, inhibition of mTOR can augment autophagy to remove misfolded proteins generated from mutant genes. mTOR inhibition can suppress ER stress-induced apoptosis by regulating retina protein biosynthesis and degradation.
