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. 2017 Jan 20;18(1):207. doi: 10.3390/ijms18010207

Figure 5.

Figure 5

Concentration-dependent effects of CHs on the activities of aggrecanases. The activities of rhADAMTS4 (A) and rhADAMTS5 (B) in the presence or absence of 0.1, 0.5, 1, 2 and 10 mg/mL of Mobiforte®, Peptan® F 5000 or Peptan® F 2000 were determined using the rhAggrecan-IGD as a substrate. The activities of both aggrecanases are expressed as the percentage of untreated controls (=100%). Data are shown as the mean + SD (n = 4–6). Significant differences between treated and untreated controls (100%) were defined with p-values as follows: * 0.01< p ≤ 0.05, ** 0.001 < p ≤ 0.01.