Table 1.

Changes in renal parameters after a bolus injection of atrial natriuretic peptide (ANP) (2.0 µg/kg) in 12 patients with chronic heart failure (CHF) and 13 healthy controls

	Patients with CHF (n = 12)	Controls (n = 13)	P‐value vs. placebo
Diuresis	−3.4	+62	<0.01
Natriuresis	+57	+120	0.109
Fractional Na+ excretion	+44	+99	0.121
Proximal fractional Na+ reabsorption	−1.8	−4.8	<0.01
Distal fractional Na+ reabsorption	−0.9	−4.7	<0.01
Plasma cGMP	+138	+615	<0.01
Urinary cGMP	+131	+729	<0.01

cGMP, cyclic guanosine monophosphate

Results are shown as percentage change from baseline to after ANP injection. Adapted from Eiskjaer et al. 12 with permission.