Table 3.
Statistical Comparison of Log‐Transformed Atorvastatin, Digoxin, Metformin, and Methotrexate PK Parameters
| Geometric Least‐Squares Mean Ratio, % (90% Confidence Interval)a | |||||
|---|---|---|---|---|---|
| Parameter | Atorvastatin | Digoxin | Metformin | Methotrexate | 7‐Hydroxymethotrexate |
| AUC∞ | 137 (129, 145) | 125 (117, 134) | 152 (138, 168) | 97 (90, 104.6) | 129 (119, 141) |
| AUClast | 138 (129, 149) | 124 (116, 133) | 150 (137, 165) | 97 (90, 104.7) | 124 (114, 135) |
| Cmax | 103 (88, 121) | 133 (119, 149) | 123 (109, 140) | 89 (83, 97) | 115 (104, 127) |
AUC, area under the concentration‐time curve; Cmax, maximum concentration.
a
Results based on a mixed‐effects model of natural log‐transformed parameters, with treatment as a fixed effect and subject as a random effect.