Table 3.
Statistical Analysis of the Effect of Isavuconazole on the Pharmacokinetics of Immunosuppressive Agents
| Geometric Least‐Squares Mean Ratio, % (90%CI) | |||||
|---|---|---|---|---|---|
| Parameter | Cyclosporine | Mycophenolic Acid | Prednisolone | Sirolimus | Tacrolimus |
| AUC0–∞ | 129 (115, 144) | 135 (127, 145) | 108 (102, 114) | 184 (159, 213) | 225 (191, 266) |
| AUClast | 129 (115, 144) | 132 (124, 141) | 108 (102, 114) | 208 (181, 239) | 227 (192, 268) |
| Cmax | 106 (95, 119) | 89 (76, 103) | 96 (90, 102) | 165 (141, 192) | 142 (122, 164) |
AUC, area under the concentration‐time curve; CI, confidence interval; Cmax, maximum concentration.