Table 4.
Pharmacokinetics of Isavuconazole
| Cyclosporine | Mycophenolate Mofetil | Prednisone | Sirolimus | Tacrolimus | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Parameter | Isavuconazole Alone (n = 21) | CSA + Isavuconazole (n = 19) | Isavuconazole Alone (n = 22) | MMF + Isavuconazole (n = 22) | Isavuconazole Alone (n = 20) | PRE + Isavuconazole (n = 20) | Isavuconazole Alone (n = 21) | SIR + Isavuconazole (n = 21) | Isavuconazole Alone (n = 21) | TAC + Isavuconazole (n = 21) |
| AUCτ, μg·h/mLa | 107.7 (31.2) | 109.3 (29.2) | 101.4 (37.6) | 100.5 (32.3) | 88.2 (37.9) | 98.8 (36.6) | 92.0 (21.0) | 100.4 (24.2) | 89.8 (33.8) | 100.4 (35.5) |
| Cmax, μg/mLa | 5.7 (1.9) | 7.3 (1.8) | 6.5 (2.1) | 6.7 (2.0) | 5.6 (1.9) | 6.7 (2.4) | 6.2 (1.4) | 6.4 (1.5) | 4.9 (1.6) | 6.10 (1.7) |
| tmax, hours | 3.0 (0.5‐8.0) | 4.0 (3.0‐5.0) | 3.0 (1.0‐4.0) | 3.0 (1.5‐5.0) | 2.0 (1.5‐3.0) | 3.0 (1.5‐5.0) | 2.0 (1.5‐3.0) | 3.0 (2.0‐4.0) | 3.0 (0.3‐8.0) | 3.0 (1.5‐8.0) |
| Geometric Least‐Squares Mean, % (90%CI) | ||||||||||
| AUCτ | 103 (100, 106) | 101 (98, 103) | —b | 111 (109, 114) | 112 (110, 115) | |||||
| Cmax | 130 (121, 139) | 104 (100, 107) | —b | 104 (100, 108) | 126 (118, 134) | |||||
AUC, area under the concentration‐time curve; Cmax, maximum concentration; CI, confidence interval; CSA, cyclosporine; MMF, mycophenolate mofetil; PRE, prednisone; SIR, sirolimus; TAC, tacrolimus; tmax, time to maximum concentration.
a
AUCτ and Cmax values are expressed as arithmetic mean (standard deviation); tmax is expressed as median (range).
b
Not calculated.