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Scheme for the second round of compound optimization. Starting from bedaquiline, both chiral carbon atoms in the first round of optimization were removed, and a new scaffold of 2‐oxy‐3‐phenyl‐6‐bromoquinoline with potent anti‐TB activity was obtained. In the second round of optimization, the substituents of this new scaffold were changed to improve the anti‐TB activity of these new compounds.
