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. 2016 Oct 28;12(2):106–119. doi: 10.1002/cmdc.201600441

Scheme 3.

Scheme 3

Synthesis of N‐linked compounds 16. Reagents and conditions: a) hydrocinnamoyl chloride, Et3N, CH2Cl2, RT, 5 h, 93.6–98.2 %; b) POCl3, DMF, 100 °C, 16 h, 46.0–82.2 %; c) NaOMe/MeOH, reflux, 6 h, 98.2–99.3 %; d) NBS/CCl4, reflux, 3 h; e) 1. substituted aniline, K2CO3, DMF, RT, 2 h, or 2. multistep (see Supporting Information for details).