Table 2.

In vitro antitubercular activity of series 2 compounds.^[a]

Compd	R1	R2		MIC		CC50 [b]
				μg mL−1	μm	μg mL−1	μm
16 a		H		7.7	17.0	14	30.9
16 b		H		6.4	13.7	12	25.7
16 c		H		3.8	8.9	8.9	20.8
16 d		Br		4.2	8.3	30	59.3
16 e		Br		>32	>67.5	>64	>135.0
16 f		Br		2.0	4.0	9.2	18.4

[a] Reference compound: bedaquiline MIC=0.060 μg mL⁻¹ (0.1 μm). [b] Concentration at which the growth of Vero cells is inhibited by 50 %.