Table 6.

In vitro antitubercular activity of compounds from the second round of optimization.^[a]

Compd	R1	R2		MIC		CC50 [b]
				μg mL−1	μm	μg mL−1	μm
34 a		H		0.62	1.5	4.0	9.6
34 b		Br		1.6	3.7	11	25.4
34 c		Br		2.5	5.6	7.8	17.4
34 d		Br		2.0	4.3	12	26.0
34 e		Br		0.81	1.7	6.2	12.9
34 f		Br		0.58	1.2	4.4	9.2
34 g		Br		5.2	10.9	5.6	11.7
34 h		Br		0.72	1.5	7.4	15.9
34 i		Br		0.55	1.1	11	22.9
34 j		Br		1.5	3.1	4.2	8.7
34 k		Br		0.89	1.7	14	26.8
34 l		Br		0.79	1.5	5.0	9.3
34 m		Br		0.43	0.95	3.0	6.7
34 n		Br		0.71	1.5	9.7	20.9
34 o		Br		1.6	3.9	12	29.4
34 p		Br		5.9	15.9	17	45.8

[a] Reference compound: bedaquiline MIC=0.060 μg mL⁻¹ (0.1 μm). [b] Concentration at which the growth of Vero cells is inhibited by 50 %.