Figure 8.

The effect of AZD7762 on the growth delay induced by ¹³¹I‐MIP‐1095 in LNCaP spheroids. The effect of AZD7762 on the growth delay induced by 0.37 MBq/ml ¹³¹I‐MIP‐1095 was evaluated in LNCaP spheroids. The medians of τ₂ and AUC values of the spheroids exposed to the single agent treatments were statistically compared with that of the untreated controls (*). The medians of τ₂ and AUC values of the spheroids treated with a combination of ¹³¹I‐MIP‐1095 with AZD7762 were compared with those of the spheroids treated with ¹³¹I‐MIP‐1095 alone (¶) and to those of the spheroids treated with AZD7762 alone (†). Data are mean ± SEM (n = 3), three symbols indicate P < 0.001.