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. 2016 Aug 12;4(3):19. doi: 10.3390/biomedicines4030019

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© 2016 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Vaccination into the tumor microenvironment with recombinant VV-neu leads to tumor regression, increased systemic CTL response, and reverses the systemic elevation in MDSC. (a) In a mouse HER2+ breast cancer mode, vaccination into the tumor microenvironment with recombinant vaccinia expressing the HER2/neu TAA (i.t. VV-neu + VV-GMCSF + KLH) results in a tumor specific CTL response; (b) regression of the primary tumor; (c) and a decrease in systemic MDSCs, whereas systemic treatment (s.c. VV-neu + VV-GMCSF + KHL) is not effective. Reprinted from [91], with permission from Elsevier.