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. 2017 Jan 27;2017(1):CD011305. doi: 10.1002/14651858.CD011305.pub2

Comparison 1. Restrictive versus liberal red blood cell transfusion RCTs.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 All‐cause mortality‐at 31 to 100 days 2 95 Risk Ratio (M‐H, Fixed, 95% CI) 0.25 [0.02, 2.69]
2 Mortality due to chemotherapy 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
3 Number of participants with any bleeding 2 149 Risk Ratio (M‐H, Fixed, 95% CI) 0.93 [0.73, 1.18]
4 Number of participants with clinically significant bleeding 2 149 Risk Ratio (M‐H, Fixed, 95% CI) 1.03 [0.75, 1.43]
5 Severe or life‐threatening bleeding events 2 149 Risk Ratio (M‐H, Fixed, 95% CI) 1.57 [0.39, 6.30]
6 Number of participants with serious infection episodes 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
7 Number of participants with VOD 1   Peto Odds Ratio (Peto, Fixed, 95% CI) Totals not selected
8 Number of participants with RBC transfusion from study entry 3 155 Risk Ratio (M‐H, Fixed, 95% CI) 0.97 [0.90, 1.05]
9 Number of participants with RBC Transfusion after reaching Hb >80 g/L for restrictive & Hb > 120 g/L for liberal 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected
10 Mean number of RBC (units) transfusions per participant during the entire study period 2 95 Mean Difference (IV, Fixed, 95% CI) ‐3.58 [‐5.66, ‐1.49]
11 Number of participants with PLT transfusions from the study entry 1   Risk Ratio (M‐H, Fixed, 95% CI) Totals not selected