Comparison 1. Restrictive versus liberal red blood cell transfusion RCTs.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 All‐cause mortality‐at 31 to 100 days	2	95	Risk Ratio (M‐H, Fixed, 95% CI)	0.25 [0.02, 2.69]
2 Mortality due to chemotherapy	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
3 Number of participants with any bleeding	2	149	Risk Ratio (M‐H, Fixed, 95% CI)	0.93 [0.73, 1.18]
4 Number of participants with clinically significant bleeding	2	149	Risk Ratio (M‐H, Fixed, 95% CI)	1.03 [0.75, 1.43]
5 Severe or life‐threatening bleeding events	2	149	Risk Ratio (M‐H, Fixed, 95% CI)	1.57 [0.39, 6.30]
6 Number of participants with serious infection episodes	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
7 Number of participants with VOD	1		Peto Odds Ratio (Peto, Fixed, 95% CI)	Totals not selected
8 Number of participants with RBC transfusion from study entry	3	155	Risk Ratio (M‐H, Fixed, 95% CI)	0.97 [0.90, 1.05]
9 Number of participants with RBC Transfusion after reaching Hb >80 g/L for restrictive & Hb > 120 g/L for liberal	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
10 Mean number of RBC (units) transfusions per participant during the entire study period	2	95	Mean Difference (IV, Fixed, 95% CI)	‐3.58 [‐5.66, ‐1.49]
11 Number of participants with PLT transfusions from the study entry	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected