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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: Osteoarthritis Cartilage. 2016 Apr 5;24(8):1330–1339. doi: 10.1016/j.joca.2016.03.018

Table 1.

Overview of currently used gene transfer vectors for meniscal repair

Classes Integration Advantages Shortcomings
NV no . nontoxic
. large capacity
. relatively low efficiency
. short-term expression
AdV no . high efficiency
. large capacity
. possible replication
. immunogenicity/toxicity
. short-term expression
RV/LV yes . high efficiency
. relatively large capacity
. long-term expression
. possible replication
. insertional mutagenesis
HSV no . high efficiency
. large capacity
. possible replication
. toxicity
. short-term expression
rAAV mostly episomal . high efficiency
. long-term expression
. low immunogenicity/toxicity
. difficult to produce
. size limitation
. serotype specificity

AdV: adenoviral vectors; HSV: herpes simplex virus vectors; LV: lentiviral vectors; NV: nonviral vectors; rAAV: recombinant adeno-associated virus vectors; RV: retroviral vectors.