. Author manuscript; available in PMC: 2017 Aug 1.

Published in final edited form as: Osteoarthritis Cartilage. 2016 Apr 5;24(8):1330–1339. doi: 10.1016/j.joca.2016.03.018

Table 1.

Overview of currently used gene transfer vectors for meniscal repair

Classes	Integration	Advantages	Shortcomings
NV	no	. nontoxic . large capacity	. relatively low efficiency . short-term expression
AdV	no	. high efficiency . large capacity	. possible replication . immunogenicity/toxicity . short-term expression
RV/LV	yes	. high efficiency . relatively large capacity . long-term expression	. possible replication . insertional mutagenesis
HSV	no	. high efficiency . large capacity	. possible replication . toxicity . short-term expression
rAAV	mostly episomal	. high efficiency . long-term expression . low immunogenicity/toxicity	. difficult to produce . size limitation . serotype specificity

AdV: adenoviral vectors; HSV: herpes simplex virus vectors; LV: lentiviral vectors; NV: nonviral vectors; rAAV: recombinant adeno-associated virus vectors; RV: retroviral vectors.