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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: Osteoarthritis Cartilage. 2016 Apr 5;24(8):1330–1339. doi: 10.1016/j.joca.2016.03.018

Table 2.

Overview of current in vitro gene-, cell-, and tissue engineering approaches for meniscal repair

Vector Gene Biomaterial Cells Effects References
NV IGF-I - meniscal cells cell proliferation 50
FGF-2 alginate meniscal cells cell proliferation 51
AdV TGF-β type-I collagen/GAG matrix meniscal and progenitor cells cell proliferation matrix synthesis 48
RV TGF-β - meniscal cells matrix synthesis 44
rAAV FGF-2 - meniscal and progenitor cells cell proliferation 49,53
TGF-β - meniscal cells cell proliferation matrix synthesis 52

AdV: adenoviral vectors; FGF-2: basic fibroblast growth factor; GAG: glycosaminoglycans; IGF-I: insulin-like growth factor I; NV: nonviral vectors; PGA: poly-glycolic acid; rAAV: recombinant adeno-associated virus vectors; RV: retroviral vectors; TGF-β: transforming growth factor beta.