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. 2017 Feb 8;12(2):e0171185. doi: 10.1371/journal.pone.0171185

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© 2017 Massafra et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 2 — (A) IPA of pathways enriched in mice treated with FGF19 for 12h compared to vehicle control. For the analysis, proteins with fold change ≥1.3 FGF19 over vehicle were included. Pathways related to physiology or disease that were significantly enriched (p-value < 0.01) are ranked in function of their activation z-score and grouped into functional classes. (B) Venn Diagram representation of proteins changed upon FGF19 treatment that are involved in metabolism and cell survival/cancer, inferred from the metabolic (#) and cell survival (*) pathways depicted in panel A. Fold change upon FGF19 treatment for proteins classified in metabolism, cell survival/cancer pathways or both is shown.