Table 1. Genetically modified mice used in this study.

Line (abbreviation)	Genetic modification	Description of mice used	Ref.
PrnpΔF (ΔF)	Transgenic mice expressing a truncated PrPC (32–134) on a B6129-PrnpZrchI/ZrchI background	Adult mice with signs of neurodegeneration	[31]
B6-Tg/Thy1APP23Sdz (APP23)	Transgenic mice overexpressing the human APP with the Swedish double mutation at 670/671 (KM→NL)	1.5 year-old mice with histologic evidence of astrogliosis, microgliosis and amyloid β plaque	[32]
C57BL/6J-PrnpZH3/ZH3 (ZH3)	Co-isogenic C57BL/6J mice lacking the cellular prion protein.	Adult mice	[18]