Table 4.
Summary of Regression Statistics for Models in Which TTF Is a Significant Predictor.
| Staining Measure (Dependent Variable) | Independent Variable | p Value | β Estimate (95% CI for Significant Predictors) | β Estimate (Standard Units) | Semipartial R2 |
|---|---|---|---|---|---|
| Orexin-A | TTF | 0.087 | −7.188 (−15.488, 1.111) | −0.885 | 0.072 |
| TTF × Age | 0.032 | 0.442 (0.041, 0.843) | 1.357 | 0.116 | |
| Age | 0.002 | −537.209 (−857.666, −216.752) | −0.924 | 0.269 | |
| Sex | 0.452 | −970.000 | −0.117 | 0.133 | |
| Model R2= | 0.288 | ||||
| PV | TTF | 0.045 | −10,578 (−20,871, −284.110) | −1.876 | 0.173 |
| TTF2 | 0.054 | 2.597 (−0.050, 5.244) | 1.805 | 0.157 | |
| Age | 0.723 | 55,376 | 0.074 | 0.005 | |
| Sex | 0.992 | −19,760 | −0.002 | <0.001 | |
| Model R2= | 0.206 | ||||
| DCX | TTF | 0.086 | −3.610 (−7.802, 0.582) | −0.340 | 0.104 |
| Age | 0.006 | −346.482 (−573.541, −119.423) | −0.603 | 0.325 | |
| Sex | NA | NA | NA | ||
| Model R2= | 0.611 | ||||
| proBDNF somata | TTF | 0.008 | 6.27 × 10−6 (1.79 × 10−6, 1.08 × 10−5) | 0.408 | 0.165 |
| Age | 0.004 | 8.96 × 10−4 (3.11 × 10−4, 1.48 × 10−3) | 0.449 | 0.197 | |
| Sex | 0.618 | −0.002 | −0.072 | 0.005 | |
| Model R2= | 0.352 | ||||
| proBDNF WM OD | TTF | 0.031 | 1.66 × 10−5 (1.59 × 10−6, 3.15 × 10−5) | 0.357 | 0.126 |
| Age | 0.065 | 1.83 × 10−3 (−1.23 × 10−4, 3.79 × 10−3) | 0.304 | 0.091 | |
| Sex | 0.861 | −0.002 | −0.028 | 0.001 | |
| Model R2= | 0.205 | ||||
| dMBP fluorescence intensity | TTF | 0.081 | −9.20 × 10−3 (−1.96 × 10−2, 1.24 × 10−3) | −1.935 | 0.082 |
| TTF2 | 0.036 | 2.36 × 10−6 (1.71 × 10−7, 4.55 × 10−6) | 2.388 | 0.123 | |
| Age | 0.120 | 0.180 | 0.260 | 0.064 | |
| Sex | 0.046 | 3.757 (0.074, 7.440) | 0.356 | 0.110 | |
| Model R2= | 0.405 | ||||
| HA percent area | TTF | 0.011 | −0.010 (−0.018, −0.003) | −2.564 | 0.144 |
| TTF2 | 0.003 | 2.58 × 10−6 (9.55 × 10−7, 4.20 × 10−6) | 3.067 | 0.203 | |
| Age | 0.031 | 0.191 (0.019, 0.362) | 0.323 | 0.099 | |
| Sex | 0.113 | 2.116 | 0.236 | 0.048 | |
| Model R2= | 0.548 |
The 95% CI is shown only for the β estimates of predictors that approach or attain significance. “Model R2” is the unadjusted R2 for the model that includes the variables shown. See section “Materials and Methods” for further explanation of these statistical measures. Abbreviations: TTF, total time frozen; CI, confidence interval; PV, parvalbumin; DCX, doublecortin; proBDNF, pro-brain-derived neurotrophic factor; WM, white matter; OD, optical density; dMBP, damaged myelin basic protein; HA, hyaluronic acid.