Table 2.
Multivariate analysis of factors influencing survival using a cox proportional hazards model.
| Characteristics | OS |
RFS | ||
|---|---|---|---|---|
| Hazards ratio (95% CI) |
p value | |||
| Sex | ||||
| Male | 1 | 1 | ||
| Female | 0.65 (0.53–0.80) | <0.05 | 0.93 (0.62–1.44) | NS |
| Age, years | ||||
| ⩽50 | 1 | 1 | ||
| >50 | 0.55 (0.38–0.79) | <0.05 | 1.29 (0.84–1.98) | NS |
| Tumor size | ||||
| ⩽3 cm | 1 | 1 | ||
| >3 cm | 1.13 (1.42–2.37) | NS | 0.83 (0.53–1.27) | NS |
| Lymphovascular invasion | ||||
| No | 1 | 1 | ||
| Yes | 1.17 (0.87–1.57) | NS | 1.62 (0.95–2.77) | NS |
| Lymph node metastasis | ||||
| No | 1 | 1 | ||
| Yes | 1.84 (1.42–2.37) | <0.05 | 6.25 (3.94–10.01) | <0.05 |
| Depth of invasion | ||||
| Mucosa | 1 | 1 | ||
| Submucosa | 1.28 (0.04–1.57) | <0.05 | 1.67 (0.98–1.27) | NS |
| Histology | ||||
| WD-TUB | 1 | 1 | ||
| MD-TUB | 0.74 (0.58–0.95) | <0.05 | 0.59 (0.32–1.10) | NS |
| PD-TUB | 0.88 (0.63–1.12) | NS | 0.69 (0.38–1.24) | NS |
| SRC | 0.55 (0.38–0.79) | <0.05 | 0.72 (0.34–1.54 | NS |
CI, confidence interval; MD-TUB, moderately differentiated tubular adenocarcinoma; NS, nonspecific; PD-TUB, poorly differentiated tubular adenocarcinoma; SRC, signet ring cell carcinoma; WD-TUB, well-differentiated tubular adenocarcinoma.