Figure 2.

Characteristics of systemic drug exposure in patients prescribed clozapine (n = 60). (A) Spearman correlation between clozapine and norclozapine drug level. (B) Effect of CYP2C19 phenotype and (C) smoking status on dose-normalized clozapine levels and clozapine to norclozapine ratio. Statistical analyses were performed with Kruskal-Wallis test with Dunn’s multiple-comparison or Mann-Whitney test as appropriate. EM, extensive metabolizer; IM, intermediate metabolizer; PM, poor metabolizer; UM, ultrarapid metabolizer.