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The administration of FGF21 improves insulin resistance in high-fat diet-induced obese mice. (a) Body weight. (b) Blood glucose. (c) Serum insulin. (d) Serum FGF21. (e) Glucose tolerance testing (GTT). (f) Area under the curve by GTT. (g) Insulin tolerance testing (ITT). (h) Area under the curve by ITT. ND, Normal diet; HFD, high-fat diet; Veh, vehicle. The data were expressed as mean ± SEM in each bar graph. *P < 0.05 (HFD/Veh versus ND/Veh). #P < 0.05 (HFD/FGF21 versus HFD/Veh)
