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P53 structure and function. A) Structure-function schematic of p53 showing the presence of five distinct domains that enable its transcriptional activities: i) a transcriptional activation domain (TAD); ii) a proline-rich domain (TAD-II/PRD); iii) a sequence-specific DNA-binding domain (DBD); iv) a tetramerization domain (TET) and; v) nuclear localization sequences (NLS).
