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Distribution of TP53 missense and nonsense mutations in patients with Li-Fraumeni Syndrome (LFS).A) Histogram featuring p53 missense mutations present in the germline of LFS patients. B) Histogram featuring truncating mutations present in the germline of LFS patients. Together, these plots shows that the majority of TP53 in patients with LFS mutations occur in the core domain. Labeled residues are mutation hot-spots. Exon- 6/exon-7 truncating mutations are indicated in purple.
