Table 4. Multi-phosphorylated sequences implicated as interacting with Pin1.
Name | Sequence | References |
---|---|---|
IRAK1-UD | 127AEAWpSPRKLPSSASTFLpSPAFPGSQTHSGPELGLVPpSPASLWPPPPpSPAPSSTK180 | [24] |
MGLUR5 | 1159ELVALpTPPpSPFRDSV1173 | [51] |
Separase | 1122STNSpSPVLKTKPQPIPNFLSHSPTCDCSLCApSPVLTA1158 | [52] |
Tau | 210SRpTPSLPpTPPTREPKKVAVVRpTPPKpSPS237 | [21, 53, 62] |
Cdc25c | 46PRpTPVGKFLGDSANLSILSGGpTPK69 | [14, 33, 44] |
RNA Pol II | (CTD repeat) YSPTpSPSYSPTpSPSYSPTpSPS | [33] |
Notch | 2121pSPQLHGAPLGGpTPTLpSPP2138 | [23] |
Nanog | 51VpSPLPSSMDL LIQDpSPDSSTpSPK73 | [63] |
Raf-1 | 285SESApSPSALSSpSPNNL300 | [64] |
Myt1 | 411ApTPPGpSPPCS418;440LpSPEAVLARTVGSTSpTPRSRCpTP462 | [33] |
CK2-α1 | 342GSpTPVSSANMMSGISSVPpTPpSPLGPLAGpSPVI373 | [65] |
SMRT | 1461QGpTPLKYDTGASTTGSKKHDVRSLIGpSPGR1490 | [66] |
c-Jun | 58SDLLTpSPDVGLLKLApSPEL76 | [22] |
c-Fos | 322PLCpTPVVTCpTPSC334 | [67] |
STAT3 | 712CVpTPTTCSNTIDLPMpSPRTLD732 | [68] |
Smad3 | 177PEpTPPP182;202AGpSPNLpSPN PMpSPA215 | [69, 70] |
PML | 515KAVpSPP HLDGPPpSPRS530 | [71] |
Potential Pin1 recognition motifs are shown in bold, with phosphoserine (pS) and phosphothreonine (pT) in red.