Table 2.
Plasma TGF-β concentrations by phenotype and genotype.
| TGF-β | Genotype | DTH− | DTH+ | VL | DTH+vsDTH− | VLvsDTH+ | VLvsDTH− | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | pg/ml | N | pg/ml | N | pg/ml | T-test: DTH−vsDTH+ |
Fold: VL/DTH+ |
T-test: VLvsDTH+ |
Fold: VL/DTH− |
T-test: VLvsDTH− |
||
| Total | All* | 11 | 707±192 | 19 | 940±178 | 11 | 1006±215 | P=0.382 | 1.1 | P=0.817 | 1.4 | P=0.313 |
| Total | AA | 10 | 723±211 | 15 | 906±186 | 6 | 488±166 | P=0.522 | 0.5 | P=0.113 | 0.7 | P=0.397 |
| Total | AG/GG | 1 | 552 | 4 | 1067±538 | 5 | 1627±190 | - | 1.5 | P=0.386 | - | - |
| T-test AAvsAG/GG |
- | P=0.792 | P=0.002 | |||||||||
| Activated | All* | 11 | 22±12 | 19 | 52±19 | 11 | 125±30 | P=0.198 | 2.4 | P=0.051 | 5.7 | P=0.007 |
| Activated | AA | 10 | 24±14 | 15 | 64±7 | 6 | 143±47 | P=0.154 | 2.2 | P=0.171 | 5.9 | P=0.052 |
| Activated | AG/GG | 1 | 0 | 4 | 6.9±6.9 | 5 | 104±35 | - | 15.1 | P=0.056 | - | |
| T-test AAvsAG/GG |
- | P=0.033 | P=0.285 | |||||||||
Subjects genotyped for the SNP rs6785358 near the TGFBR2 promoter were assayed for plasma levels of total and of endogenously activated forms of TGF-β.