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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Nanomedicine. 2016 Aug 9;13(2):443–454. doi: 10.1016/j.nano.2016.07.015

Figure 7.

Figure 7

Nicotine distribution in serum and brain in immunized mice. Mice were immunized with vaccines containing immunogens equivalent to 25 μg of Nic-KLH. For groups with alum, 1.5 mg was used as an adjuvant. The 6-CMUNic-KLH positive control used 0.25 or 1.5 mg of alum. Mice in the negative control group were immunized with 25 μg of KLH carrier protein alone. (A) Serum and (B) brain tissues of 4 mice were collected 4 min post administration of 0.06 mg/kg nicotine subcutaneously on Day 41. Data are expressed as means ± SD. Significantly different compared to the negative control group: *p < 0.05, **p < 0.01. Significantly different: #p < 0.05. NS indicates the brain nicotine levels between groups were comparable (p>0.98).