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. 2017 Feb 9;8:56. doi: 10.3389/fphar.2017.00056

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Copyright © 2017 Lambrecht, Jan Poortmans, Verhulst, Reynaert, Mannaerts and van Grunsven.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of vesicle-associated miRNA-150, -192, -200b, -92a during early stage HBV- and HCV-induced fibrosis. (A) The levels of plasma vesicle-associated miRNA-122, -150, -192, -21, -200b, and -92a were measured by real-time quantitative PCR, and obtained Ct levels were normalized by use of spiked-in cel-miRNA-39. (B) Curves of receiver operating characteristic (ROC) analysis using the differentially expressed vesicle-associated miRNA-150, -192, -200b, and -92a for discriminating early stage HBV (blue) and HCV (red) fibrotic patients versus healthy controls. ^∗∗P < 0.01; ^∗∗∗P < 0.001; ^∗∗∗∗P < 0.0001.