Figure 4.

Mitochondrial activity is modified in response to 5-HT. (A) Effect of inhibitors of the complex III and I of the mitochondrial respiratory chain (Antimycin A, 10 μM and rotenone, 100 nM, dark and light gray columns respectively) is shown on the ${{\text{O}}_2}^{\underset{\_}{•}}$ produced by 100 μM 5-HT in rat IPA. n is the number of vessels. (B) Illustrates mitochondrial activity, expressed as a % of basal respiratory rate in response to cumulative concentrations of 5-HT (1 to 100 μM) in PASMC. n is the number of rats. Data are expressed as mean ± SEM. ^** and ^* mean a significant difference for P < 0.01 and P < 0.05 respectively.