Table 1.

microRNAs (miRNAs) in the lymphatic endothelium.

miRNA	Primary role	Function and target	Model system	Reference
miR-126	Angiogenesis	Highest expressed miRNA in endothelial cells, which regulates angiogenesis through SPRED1 and VCAM-1	Human primary ECs, murine ECs	Wang et al. (38), Harris et al. (37), and Fish et al. (39)
	Inflammation
miR-132	Angiogenesis	Acts as an angiogenic switch by targeting p120RasGAP	Human umbilical vein ECs	Anand et al. (41)
	Inflammation	Regulates anti-viral immunity through EP300	Kaposi’s sarcoma herpesvirus (KSHV)-infected lymphatic endothelial cell (LECs)	Lagos et al. (82)
miR-9	Inflammation	Regulates vascular endothelial growth factor receptor-3 (VEGFR-3), lymphangiogenesis, and NF-κB signaling	Rat LECs and human primary LECs	Chakraborty et al. (88)
miR-1236	Inflammation	Induced by IL-1β and regulates VEGFR-3 and lymphangiogenesis	Cultured human dermal LECs	Jones et al. (89)
miR-181a	Lineage commitment	Blood endothelial cell (BEC)-expressed miRNA, which inhibits PROX1 in LEC development	Murine LECs	Kazenwadel et al. (22)
miR-31	Lineage commitment	BEC-expressed miRNA which inhibits PROX1 and FOXC2 in LEC development	Human primary LECs, xenopus, and zebrafish	Pedrioli et al. (40)
miR-466	Lineage commitment	Inhibits PROX1 and tube formation	HDLECs and corneal lymphatic vessels	Seo et al. (52)
miR-K12-6, miR-K12-11 (ortholog of miR-155)	Lineage commitment	Viral miRNAs that target c-MAF contributing to virus-induced LEC reprograming	KSHV-infected LECs	Hansen et al. (31) and Hong et al. (91)
miR-146a/b	Inflammation	Early-response miRNA involved in TLR4 signaling and innate immunity	KSHV-infected LECs	Lagos et al. (82)
miR-155	Inflammation	Targets ETS-1 upstream of endothelial adhesion molecules such as VCAM-1	Human umbilical vein ECs	Zhu et al. (87)
	Angiogenesis
miR-221/miR-222	Angiogenesis	Targets transcription factors ETS-2 and ETS-1, respectively, regulating EC motility	Human primary LECs, KSHV-infected LECs	Wu et al. (93)